BIOMARKER ANALYSIS

BIOMARKER ANALYSIS

Kymos is a GLP-certified and GCP-compliant multinational CRO inspected by the EMA and FDA. Our team of experts provides biomarker analysis, supporting you across all phases, from drug discovery to clinical sample analysis reaching multiple therapeutic areas.

Equipped with state-of-the-art technologies and techniques such as Meso Scale Discovery (MSD®), Luminex®, qPCR, and LC-MS/MS, we offer a comprehensive catalog of biomarkers. This combination of expertise and technologies allows us to adapt and customize the biomarker determination according to each Clinical or Preclinical study’s specific needs.

We are proficient in developing new methods from scratch, and depending on the study scope we can perform fit-to-purpose qualification or validation. Our team is experienced in pharmacodynamic studies to determine drug efficacy and safety (End-point determination), performing biomarker exploratory determinations, and screening of inflammatory markers as inclusion criteria for clinical studies.

Meso QuickPlex SQ

Biomarker Analysis Services

OUR MAIN SERVICES 

  • Protein (cytokines, hormones, antibodies, growth factors, etc.) biomarker analysis (MSD®, Luminex®)
  • Genetic (RNA, mRNA, miRNA, etc.)  biomarker analysis (qPCR, Hybridization ELISA, LC-MS/MS, MSD®)
  • Small molecule biomarker analysis (LC-MS/MS)
  • Fit-to-purpose biomarker immunoassay qualification and validation
  • Exploratory screenings of biomarkers for use as an endpoint in future clinical trials
  • Development of methods from scratch
  • Customized multiplexing panels
  • Pharmacodynamic studies for drug efficacy and safety
  • Broad spectrum of species (human, mouse, non-human primate (NHP), rat, canine, chicken, pig, and others)
  • Determination in several matrices (plasma, serum, cerebrospinal fluid (CSF), cell culture supernatant, cell homogenates, urine, saliva, and others)

Biomarker Therapeutic Areas

INFLAMMATORY BIOMARKERS

NEUROLOGY BIOMARKERS

  • Inflammatory panels (IFN-γ, TNF-α, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, CRP and more)
  • Cytokine and Chemokine panels (MCP-1, MCP-4, Eotaxin, IP-10, MDC, TARC, MIP-1α, MIP-1α, MIP-1β, MIP-3α,, GM-CSF, IL-15, IL-16, IL-17A, TSLP, TNF- β and more)
  • Neurology and Neuroinflammation panels  (Aβ38, Aβ40, Aβ42, APP, Tau, pTau (p231-Tau), BDNF, α-Synuclein, Neurofilament L (NfL), Neurofilament H (NfH), YKL40/ CHI3L1, S100B and more)

ONCOLOGY BIOMARKERS

VASCULAR AND ANGIOGENESIS BIOMARKERS

  • Oncology panels (Galectin, BTLA, AFP, CA-9, CA125, CA15-3, CD27, CD28, CD40, CD80/B7-1, CD86/B7-2, CEA, CTLA-4, TIM-3, TLR-2, sFas, sFasL, Osteopontin, PD-L1, hyaluronidase and more)
  • Vascular and Angiogenesis panels (FGF, VEGFR, VEGF-A, VEGF-C, VEGF-D, ICAM-1, VCAM-, Ang-1, Ang-2 to name a few)

CARDIOLOGY BIOMARKERS

SYSTEMIC DISEASE BIOMARKERS

  • Cardiovascular and Cardiac Injury panels (BNP, NT proBNP, NT proANP, Follistatin, Myoglobin, CK, CK-MB, Troponin I, Troponin T, HGF, FABP3, Tissue Factor )
  • Kidney Injury panels (Albumin, Calbindin, Clusterin, HAVCR1/KIM-1, Osteoactivin, TFF3, VEGF-A)
  • Metabolic panels (Insulin, Leptin, GIP, GLP-1, C-Peptide, Lipocalin-2, Adiponectin, ApoA1, ApoC3, Clusterin)

MSD® (ECLA) for Protein Multiplex Analysis

Equipped with MESO Quickplex SQ 120 Meso Scale Discovery, Kymos offers protein biomarker analysis using multiplex immunoassays based on electrochemiluminescence (ECLA).

  • Single or multiplex assays with up to 10 analytes for well. Save time and resources with simultaneous determination of proteins.
  • Higher sensitivity than ELISA with the lower limit of detection (LLOD) in fg/mL and broad dynamic range (4-5 logs).
  • Assay kits to cover specific needs and criteria:
    • V-PLEX: Pre-validated single and multiplex assays
    • U-PLEX: Flexible and customized multiplex assays
    • S-PLEX:  Ultrasensitivity demanding assays
    • R-PLEX: Development of custom singleplex assays
    • T-PLEX: Low volume samples, ultra-sensitive, and complex matrices (sputum, vaginal fluids, etc) assays
  • Choose your biomarker combination in the MSD® catalog of assay kits. We can customize a panel according to your needs.
Image of the MESO Quickplex SQ 120 Meso Scale Discovery equipment
immunlogical laboratory

Luminex® Multiplexing Technology for Biomarkers

Luminex xMAP® technology is a bead-based immunoassay that gives the advantage of simultaneously detecting and quantifying several analytes in a single well by multiplexing.

  • Single or multiplex assays adapted and customized to each study’s specific needs with comparable accuracy and sensitivity as ELISA.
  • Up to 80 analytes in a single well and an enhanced dynamic range of up to 5.5 logs.
  • Low volume of sample needed, with less than 25 uL.
  • + 600 protein targets from different species.

Why choose KYMOS to support your biomarker analysis needs

We are FDA and EMA-inspected, GLP-certified, and committed to GCP compliance, ensuring the highest standards in biomarker analysis. As a trusted and reliable partner to pharmaceutical innovators worldwide, we specialize in providing cutting-edge biomarker analysis services across various therapeutic areas aided by our state-of-the-art equipment and multiplexing techniques.

We are fully committed to delivering a high-quality service with tight timelines and sustainable prices matching the needs of the biomarkers market.

Related Services to Biomarker Analysis

Bioanalysis of Biologics and Biosimilars

Method development and validation and sample measurement of biologics and biosimilars.

Nucleic Acids Analysis

Quantification of nucleic acids as therapeutics, biomarkers or similar with standardized and reproducible methods according to GLP.

Bioanalysis of Small Molecules

Development and validation of analytical methods for analysis of biological samples delivered mainly from pre-clinical and clinical studies.

Cell-Based and Potency Assays

We offer GLP Cell-based neutralizing antibody assays for biologics and GMP Cell-based potency assays for vacines and other biologics.

DO YOU NEED MORE INFORMATION OR A QUOTE?

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