{"id":47954,"date":"2026-09-01T09:00:21","date_gmt":"2026-09-01T07:00:21","guid":{"rendered":"https:\/\/kymos.com\/?p=47954"},"modified":"2026-09-01T09:00:21","modified_gmt":"2026-09-01T07:00:21","slug":"%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e8%8d%af%e7%89%a9%ef%bc%9a%e6%94%b9%e5%8f%98%e8%82%bf%e7%98%a4%e5%ad%a6%e6%a0%bc%e5%b1%80%e7%9a%84%e7%89%b9%e6%b4%9b%e4%bc%8a%e6%9c%a8%e9%a9%ac","status":"publish","type":"post","link":"https:\/\/kymos.com\/zh-hans\/news\/%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e8%8d%af%e7%89%a9%ef%bc%9a%e6%94%b9%e5%8f%98%e8%82%bf%e7%98%a4%e5%ad%a6%e6%a0%bc%e5%b1%80%e7%9a%84%e7%89%b9%e6%b4%9b%e4%bc%8a%e6%9c%a8%e9%a9%ac\/","title":{"rendered":"\u6297\u4f53\u5076\u8054\u836f\u7269\uff1a\u6539\u53d8\u80bf\u7624\u5b66\u683c\u5c40\u7684\u201c\u7279\u6d1b\u4f0a\u6728\u9a6c\u201d"},"content":{"rendered":"<p><span style=\"font-size: 14pt;\">\u6297\u4f53\u5076\u8054\u836f\u7269 (ADC) \u5df2\u8fc5\u901f\u6210\u4e3a\u6700\u5177\u53d8\u9769\u6027\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u7c7b\u522b\u4e4b\u4e00\uff0c\u5c24\u5176\u662f\u5728\u80bf\u7624\u5b66\u9886\u57df\u3002<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">ADCs \u7ed3\u5408\u4e86\u5355\u514b\u9686\u6297\u4f53\u7684\u7279\u5f02\u6027\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u6548\u529b\uff0c\u5c06\u9776\u5411\u7597\u6cd5\u76f4\u63a5\u9012\u9001\u81f3\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u8131\u9776\u6548\u5e94\u3002<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u81ea 2000 \u5e74\u9996\u4e2a ADC \u83b7\u5f97 FDA \u6279\u51c6\u4ee5\u6765\uff0c\u8be5\u9886\u57df\u8fc5\u901f\u6269\u5f20\uff0c\u76ee\u524d\u5df2\u6709 15 \u79cd ADC \u4e0a\u5e02\uff0c2024 \u5e74\u7684\u9500\u552e\u989d\u8fbe\u5230 136 \u4ebf\u7f8e\u5143\u3002\u5728\u9776\u5411\u7597\u6cd5\u7684\u7ade\u4e89\u4e2d\uff0c\u76ee\u524d\u6709 200 \u591a\u79cd ADC \u5019\u9009\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u53cd\u6620\u51fa\u8fd9\u4e00\u521b\u65b0\u9886\u57df\u65e5\u76ca\u589e\u957f\u7684\u52bf\u5934\u548c\u6295\u8d44\u3002 <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u5c06\u63a2\u8ba8 ADCs \u5728\u73b0\u4ee3\u533b\u5b66\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u53ca Kymos \u96c6\u56e2\u5982\u4f55\u901a\u8fc7\u8868\u5f81\u3001\u8d28\u91cf\u63a7\u5236\u548c\u7a33\u5b9a\u6027\u7814\u7a76\u4e3a\u5f00\u53d1\u4eba\u5458\u63d0\u4f9b\u652f\u6301\u3002<\/span><\/p>\n<h2><span style=\"font-size: 18pt;\"><strong>ADC \u7b80\u4ecb\uff1a\u7ed3\u6784\u3001\u4f5c\u7528\u673a\u5236\u548c\u9002\u5e94\u75c7 <\/strong><\/span><\/h2>\n<p><span style=\"font-size: 14pt;\">ADCs \u7531\u4e09\u4e2a\u4e3b\u8981\u90e8\u5206\u7ec4\u6210\uff1a<\/span><\/p>\n<ol>\n<li><span style=\"font-size: 14pt;\"><strong>\u6297\u4f53<\/strong>\uff1a\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u8bc6\u522b\u5e76\u7ed3\u5408\u9776\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u7279\u5b9a\u6297\u539f\u3002<\/span><\/li>\n<li><span style=\"font-size: 14pt;\"><strong>\u7ec6\u80de\u6bd2\u6027\u6709\u6548\u8f7d\u8377<\/strong>\uff1a\u9ad8\u6548\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u65e8\u5728\u5185\u5316\u540e\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u6216\u7834\u574f\u3002\u5e38\u89c1\u7684\u6709\u6548\u8f7d\u8377\u5305\u62ec\u5fae\u7ba1\u6291\u5236\u5242\u548c DNA \u635f\u4f24\u5242\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c3d\u7ba1 ADCs \u8fc5\u901f\u6269\u5f20\uff0c\u4f46\u7ecf\u8fc7\u4e34\u5e8a\u9a8c\u8bc1\u7684\u6709\u6548\u8f7d\u8377\u6570\u91cf\u4ecd\u7136\u6709\u9650\uff0c\u5f00\u53d1\u4f9d\u8d56\u4e8e\u4e00\u5c0f\u7ec4\u6210\u719f\u7684\u7ec6\u80de\u6bd2\u6027\u6709\u6548\u8f7d\u8377\u3002\u7136\u800c\uff0c\u4e00\u9879\u65b0\u5174\u7684\u8fdb\u5c55\u662f\u5728\u5355\u4e2a\u5076\u8054\u7269\u4e2d\u52a0\u5165\u4e24\u79cd\u5177\u6709\u4e92\u8865\u4f5c\u7528\u673a\u5236\u7684\u4e0d\u540c\u7ec6\u80de\u6bd2\u6027\u5242\uff0c\u4ece\u800c\u4ea7\u751f\u80fd\u591f\u589e\u5f3a\u6d3b\u6027\u5e76\u514b\u670d\u8010\u836f\u6027\u7684\u53cc\u8f7d\u8377 ADCs\u3002   <\/span><\/li>\n<li><span style=\"font-size: 14pt;\"><strong>\u8fde\u63a5\u5b50<\/strong>\uff1a\u5c06\u6297\u4f53\u4e0e\u6709\u6548\u8f7d\u8377\u7ed3\u5408\u7684\u5173\u952e\u7ec4\u4ef6\u3002\u8fde\u63a5\u5b50\u5fc5\u987b\u8db3\u591f\u7a33\u5b9a\uff0c\u4ee5\u4f7f\u836f\u7269\u5728\u5faa\u73af\u4e2d\u4fdd\u6301\u4e0e\u6297\u4f53\u7684\u8fde\u63a5\uff0c\u9632\u6b62\u8fc7\u65e9\u91ca\u653e\uff0c\u540c\u65f6\u5728\u8fdb\u5165\u9776\u7ec6\u80de\u540e\u80fd\u591f\u5b9e\u73b0\u9ad8\u6548\u4e14\u53d7\u63a7\u7684\u91ca\u653e\u3002\u8fde\u63a5\u5b50\u7684\u9009\u62e9\u5bf9\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6709\u91cd\u5927\u5f71\u54cd\uff0c\u56e0\u4e3a\u8fc7\u65e9\u91ca\u653e\u4f1a\u5bfc\u81f4\u8131\u9776\u6bd2\u6027\uff0c\u800c\u8fc7\u4e8e\u7a33\u5b9a\u7684\u8fde\u63a5\u5b50\u53ef\u80fd\u4f1a\u964d\u4f4e\u7597\u6548\u3002\u8fde\u63a5\u5b50\u5206\u4e3a\u53ef\u88c2\u89e3\u548c\u4e0d\u53ef\u88c2\u89e3\u4e24\u7c7b\u3002\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u65e8\u5728\u5229\u7528\u7ec6\u80de\u5185\u6761\u4ef6\uff08\u5982\u9176\u6d3b\u6027\u4ee5\u53ca\u8fd8\u539f\u548c\u9178\u6027\u73af\u5883\uff09\uff0c\u800c\u4e0d\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u65e8\u5728\u4fdd\u6301\u5b8c\u6574\uff0c\u76f4\u5230 ADC \u88ab\u5b8c\u5168\u5185\u5316\u4e14\u6297\u4f53\u5728\u7ec6\u80de\u5185\u964d\u89e3\uff0c\u4ece\u800c\u91ca\u653e\u6d3b\u6027\u836f\u7269\u3002    <\/span><\/li>\n<\/ol>\n<p><span style=\"font-size: 14pt;\">\u6b63\u5982\u5176\u7ed3\u6784\u6240\u793a\uff0cADCs \u7684\u4f5c\u7528\u673a\u5236\u5305\u62ec\u6297\u4f53\u4e0e\u9776\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u6297\u539f\u7279\u5f02\u6027\u7ed3\u5408\u3001ADC-\u6297\u539f\u590d\u5408\u7269\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u5185\u5316\u3001\u901a\u8fc7\u88c2\u89e3\u6216\u6297\u4f53\u964d\u89e3\u91ca\u653e\u836f\u7269\uff0c\u4e00\u65e6\u91ca\u653e\uff0c\u836f\u7269\u5c31\u4f1a\u5e72\u6270\u5173\u952e\u7684\u7ec6\u80de\u8fc7\u7a0b\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">ADCs \u76ee\u524d\u88ab\u6279\u51c6\u7528\u4e8e\u591a\u79cd\u9002\u5e94\u75c7\uff0c\u4e3b\u8981\u662f\u5728\u80bf\u7624\u5b66\u9886\u57df\uff0c\u5305\u62ec\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\uff08\u5982\u4e73\u817a\u764c\u548c\u5c3f\u8def\u4e0a\u76ae\u764c\uff09\u3002\u9664\u764c\u75c7\u5916\uff0cADCs \u4e5f\u5728\u5176\u4ed6\u6cbb\u7597\u9886\u57df\uff08\u5982\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff09\u8fdb\u884c\u63a2\u7d22\u3002 <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">ADCs \u6709\u52a9\u4e8e\u4e3a\u96be\u6cbb\u6027\u764c\u75c7\u60a3\u8005\u6269\u5927\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5b9e\u73b0\u66f4\u7cbe\u786e\u3001\u8010\u53d7\u6027\u66f4\u597d\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u6700\u7ec8\u6709\u52a9\u4e8e\u6539\u5584\u9884\u540e\u5e76\u63d0\u4f9b\u66f4\u5148\u8fdb\u7684\u80bf\u7624\u62a4\u7406\u65b9\u6cd5\u3002<\/span><\/p>\n<h2><span style=\"font-size: 18pt;\"><strong>Kymos \u96c6\u56e2\u652f\u6301 ADC \u5206\u6790\u6311\u6218 <\/strong><\/span><\/h2>\n<p><span style=\"font-size: 14pt;\">\u6297\u4f53\u5076\u8054\u836f\u7269\u662f\u7ed3\u6784\u590d\u6742\u7684\u5206\u5b50\uff0c\u7ed3\u5408\u4e86\u6297\u4f53\u3001\u9ad8\u6548\u6709\u6548\u8f7d\u8377\u548c\u5316\u5b66\u8fde\u63a5\u5b50\u3002\u8fd9\u79cd\u590d\u6742\u6027\u5e26\u6765\u4e86\u51e0\u4e2a\u5173\u952e\u7684\u5206\u6790\u6311\u6218\u3002\u5728 Kymos \u96c6\u56e2\uff0c\u6211\u4eec\u5c06\u5c16\u7aef\u7684\u5206\u6790\u6280\u672f\u4e0e\u751f\u7269\u5236\u836f\u5206\u6790\u65b9\u9762\u7684\u6df1\u539a\u4e13\u4e1a\u77e5\u8bc6\u76f8\u7ed3\u5408\uff0c\u4e3a ADC \u5f00\u53d1\u4eba\u5458\u63d0\u4f9b\u652f\u6301\u3002  <\/span><\/p>\n<h3><span style=\"font-size: 14pt;\"><strong>\u5f02\u8d28\u6027<\/strong><\/span><\/h3>\n<p><span style=\"font-size: 14pt;\">ADCs \u901a\u5e38\u4ee5\u5177\u6709\u4e0d\u540c\u836f\u7269\u6297\u4f53\u6bd4 (DAR)\u3001\u4e0d\u540c\u5076\u8054\u4f4d\u70b9\u548c\u53ef\u53d8\u6709\u6548\u8f7d\u8377\u5206\u5e03\u7684\u6df7\u5408\u7269\u5f62\u5f0f\u5b58\u5728\u3002\u6d4b\u91cf\u548c\u63a7\u5236\u8fd9\u79cd\u5f02\u8d28\u6027\u5bf9\u4e8e\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u548c\u76d1\u7ba1\u5408\u89c4\u6027\u81f3\u5173\u91cd\u8981\u3002\u5728 Kymos\uff0c\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5168\u9762\u7684\u5206\u6790\u5de5\u5177\u7bb1\u548c\u6211\u4eec\u56e2\u961f\u7684\u4e13\u4e1a\u77e5\u8bc6\u6765\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\u3002\u6211\u4eec\u7684\u4e00\u4e9b\u6d3b\u52a8\u5305\u62ec\uff1a   <\/span><\/p>\n<ul>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7 LC-MS \u6d4b\u5b9a ADC \u5b8c\u6574\u8d28\u91cf<\/span><\/li>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7 HPLC \u6d4b\u5b9a\u836f\u7269\u6297\u4f53\u6bd4 (DAR)<\/span><\/li>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7 LC-MS \u5206\u6790\u6709\u6548\u8f7d\u8377\u7684\u6570\u91cf\u548c\u4f4d\u7f6e<\/span><\/li>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7 LC-MS \u8bc4\u4f30\u5076\u8054\u524d\u540e\u7684\u7cd6\u57fa\u5316\u5b8c\u6574\u6027<\/span><\/li>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7\u80bd\u56fe\u5206\u6790 (LC-MS\/MS) \u9884\u6d4b\u5355\u514b\u9686\u6297\u4f53\u4e2d\u7684\u5076\u8054\u4f4d\u70b9<\/span><\/li>\n<li><span style=\"font-size: 14pt;\">\u901a\u8fc7 LC-MS \u6d4b\u5b9a\u6e38\u79bb\u836f\u7269\u548c\u6e38\u79bb\u836f\u7269\u76f8\u5173\u6742\u8d28 (FDRI)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-size: 14pt;\"><strong>\u7a33\u5b9a\u6027\u548c\u964d\u89e3<\/strong><\/span><\/h3>\n<p><span style=\"font-size: 14pt;\">\u8fde\u63a5\u5b50\u53ef\u80fd\u5bf9 pH \u503c\u3001\u6e29\u5ea6\u6216\u9176\u6d3b\u6027\u654f\u611f\uff0c\u53ef\u80fd\u5bfc\u81f4\u6709\u6548\u8f7d\u8377\u8fc7\u65e9\u91ca\u653e\u3001\u7ed3\u6784\u53d8\u5316\u6216\u805a\u96c6\u3002\u56e0\u6b64\uff0c\u5fc5\u987b\u4ed4\u7ec6\u76d1\u6d4b\u7a33\u5b9a\u6027\uff0c\u4ee5\u786e\u4fdd\u5728\u6574\u4e2a\u4ea7\u54c1\u751f\u547d\u5468\u671f\u5185\u7ef4\u6301\u6240\u6709\u5173\u952e\u8d28\u91cf\u5c5e\u6027 (CQAs)\u3002\u5728 Kymos \u96c6\u56e2\uff0c\u6211\u4eec\u901a\u8fc7\u7b26\u5408 ICH \u6807\u51c6\u7684\u7a33\u5b9a\u6027\u7814\u7a76\u6765\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\uff0c\u5305\u62ec\u957f\u671f\u3001\u52a0\u901f\u3001\u4f7f\u7528\u4e2d\u548c\u70ed\u5faa\u73af\u7a0b\u5e8f\u3002\u8fd9\u4e9b\u7814\u7a76\u7531\u5168\u9762\u7684\u5206\u6790\u5c0f\u7ec4\u652f\u6301\uff0c\u4ee5\u8bc4\u4f30 ADC \u5728\u5404\u79cd\u50a8\u5b58\u548c\u5904\u7406\u6761\u4ef6\u4e0b\u7684\u5b8c\u6574\u6027\u548c\u751f\u7269\u6d3b\u6027\u7b49\u5173\u952e\u65b9\u9762\u3002   <\/span><\/p>\n<h3><span style=\"font-size: 14pt;\"><strong>\u6548\u4ef7\u548c\u751f\u7269\u6d3b\u6027<\/strong><\/span><\/h3>\n<p><span style=\"font-size: 14pt;\">ADCs \u5fc5\u987b\u4fdd\u7559\u6297\u4f53\u7ed3\u5408\u548c\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u8fd9\u4e24\u8005\u90fd\u53ef\u80fd\u53d7\u5230\u5076\u8054\u6216\u964d\u89e3\u7684\u5f71\u54cd\u3002\u4f7f\u7528 ELISA \u548c\u57fa\u4e8e\u7ec6\u80de\u7684\u5206\u6790\u65b9\u6cd5\u6d4b\u91cf\u6297\u4f53\u7ed3\u5408\u6d3b\u6027\u548c\u751f\u7269\u5b66\u529f\u80fd\u5728\u6548\u4ef7\u6d4b\u5b9a\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5728 Kymos\uff0c\u6211\u4eec\u62e5\u6709\u591a\u5e74\u4f7f\u7528\u8fd9\u4e24\u79cd\u6280\u672f\u5904\u7406\u5305\u62ec ADCs \u5728\u5185\u7684\u5404\u79cd\u751f\u7269\u5236\u54c1\u7684\u7ecf\u9a8c\u3002  <\/span><\/p>\n<h3><span style=\"font-size: 14pt;\"><strong>\u76d1\u7ba1\u5408\u89c4\u6027<\/strong><\/span><\/h3>\n<p><span style=\"font-size: 14pt;\">\u4e3a\u4e86\u6ee1\u8db3\u76d1\u7ba1\u671f\u671b\uff0cADC 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