{"id":42867,"date":"2022-03-22T14:05:45","date_gmt":"2022-03-22T13:05:45","guid":{"rendered":"https:\/\/kymos.com\/news\/prolytic-%e4%b8%8e-aeterna-zentaris-%e6%90%ba%e6%89%8b%e6%94%b9%e5%96%84%e4%ba%ba%e7%b1%bb%e5%81%a5%e5%ba%b7-20-%e8%bd%bd\/"},"modified":"2026-07-07T12:59:58","modified_gmt":"2026-07-07T10:59:58","slug":"prolytic-%e4%b8%8e-aeterna-zentaris-%e6%90%ba%e6%89%8b%e6%94%b9%e5%96%84%e4%ba%ba%e7%b1%bb%e5%81%a5%e5%ba%b7-20-%e8%bd%bd","status":"publish","type":"post","link":"https:\/\/kymos.com\/zh-hans\/news\/prolytic-%e4%b8%8e-aeterna-zentaris-%e6%90%ba%e6%89%8b%e6%94%b9%e5%96%84%e4%ba%ba%e7%b1%bb%e5%81%a5%e5%ba%b7-20-%e8%bd%bd\/","title":{"rendered":"Prolytic \u4e0e Aeterna Zentaris \u2014\u2014 \u643a\u624b\u6539\u5584\u4eba\u7c7b\u5065\u5eb7 20 \u8f7d"},"content":{"rendered":"

\u8fd1 20 \u5e74\u6765\uff0cKymos \u7684\u5fb7\u56fd\u5b50\u516c\u53f8 Prolytic \u4e00\u76f4\u966a\u4f34 Aeterna Zentaris \u5f00\u53d1\u836f\u7269\u548c\u8bca\u65ad\u4ea7\u54c1\u3002Prolytic \u8272\u8c31\u90e8\u95e8\u8d1f\u8d23\u4eba Katrin Dorfmeyer \u548c Aeterna Zentaris \u9996\u5e2d\u79d1\u5b66\u5b98 Michael Teifel \u535a\u58eb\u5411\u6211\u4eec\u4ecb\u7ecd\u4e86 \u751f\u957f\u6fc0\u7d20\u4fc3\u5206\u6ccc\u5242 macimorelin (Macrilen, Ghryvelin)<\/strong> \u8fd9\u4e00\u6709\u8da3\u7684\u9879\u76ee\uff0c\u4ed6\u4eec\u5728\u8fc7\u53bb 10 \u5e74\u91cc\u4e00\u76f4\u4e3a\u6b64\u5171\u540c\u52aa\u529b\u3002 <\/span><\/p>\n

Katrin Dorfmeyer \u9996\u5148\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u5236\u836f\u548c\u751f\u7269\u6280\u672f\u516c\u53f8\u901a\u5e38\u4f1a\u8f6c\u5411 Prolytic\uff1a\u201c\u6211\u4eec\u5728 Prolytic \u88ab\u516c\u8ba4\u4e3a\u8272\u8c31\u4e13\u5bb6\uff0c\u5373\u5229\u7528 LC-MS\/MS \u8fdb\u884c \u5c0f\u5206\u5b50\u751f\u7269\u5206\u6790<\/a>\u3002\u8fc7\u53bb\uff0c\u5ba2\u6237\u5927\u591a\u5e26\u7740\u5177\u4f53\u4e14\u56f0\u96be\u7684\u5206\u6790\u9879\u76ee\u8054\u7cfb\u6211\u4eec\uff0c\u56e0\u4e3a\u4ed6\u4eec\u77e5\u9053\u6211\u4eec\u4f1a\u4e3a\u4ed6\u4eec\u627e\u5230\u89e3\u51b3\u65b9\u6848\u3002\u4ee5 Aeterna Zentaris \u4e3a\u4f8b\uff0c\u6211\u4eec\u5728 2003 \u5e74\u4f7f\u7528\u5f53\u65f6\u6700\u5148\u8fdb\u7684 RIA \u65b9\u6cd5\u5f00\u59cb\u4e86\u9996\u6b21\u7814\u7a76\uff0c\u4f46\u6700\u7ec8\u6210\u529f\u5f00\u53d1\u51fa\u4e00\u79cd\u521b\u65b0\u7684 LC-MS\/MS \u65b9\u6cd5\uff0c\u8fd9\u662f\u4ee5\u524d\u6ca1\u6709\u4eba\u505a\u5230\u7684\u3002\u201d <\/span><\/p>\n

\n

Teifel \u535a\u58eb\u8fd8\u56de\u987e\u4e86 Aeterna Zentaris \u4e0e Prolytic \u4e4b\u95f4\u7684\u7d27\u5bc6\u5173\u7cfb\uff1a\u201c\u591a\u5e74\u6765\uff0cProlytic \u5728\u8bb8\u591a\u4e0d\u540c\u7684\u9879\u76ee\u4e2d\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u652f\u6301\uff0c\u6d89\u53ca\u5404\u79cd\u5206\u6790\u7269\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u3001\u80bd\u6a21\u62df\u7269\u3001\u80bd\u548c\u80bd-\u836f\u7269\u5076\u8054\u7269\u3002\u5bf9\u4e8e macimorelin \u9879\u76ee\uff0c\u6211\u4eec\u4e0e Prolytic \u7684\u5408\u4f5c\u5df2\u8fd1\u4e8c\u5341\u5e74\u3002Macimorelin (Macrilen, Ghryvelin) \u662f\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u83b7\u5f97\u7f8e\u56fd FDA \u548c\u6b27\u76df\u6279\u51c6\u7684\u7528\u4e8e\u8bca\u65ad\u6210\u4eba\u751f\u957f\u6fc0\u7d20\u7f3a\u4e4f\u75c7 (AGHD) \u7684\u53e3\u670d\u68c0\u6d4b\u836f\u7269\u3002\u901a\u8fc7\u6211\u4eec\u76ee\u524d\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u4e2d\u8fdb\u884c\u7684\u6301\u7eed\u7814\u7a76\uff0c\u6211\u4eec\u7684\u76ee\u6807\u662f\u8ba9\u8fd9\u4e00\u68c0\u6d4b\u9009\u62e9\u4e5f\u80fd\u60e0\u53ca\u8fd9\u4e00\u4eba\u7fa4\u3002Katrin Dorfmeyer \u7684\u56e2\u961f\u518d\u6b21\u4ee5\u5176\u5353\u8d8a\u7684 LC-MS\/MS \u5206\u6790\u4e13\u4e1a\u77e5\u8bc6\u4e3a\u6211\u4eec\u63d0\u4f9b\u652f\u6301\u3002\u201d <\/span><\/p>\n<\/blockquote>\n

Katrin Dorfmeyer \u8fdb\u4e00\u6b65\u9610\u8ff0\u9053\uff1a\u201c\u6b63\u5982\u5df2\u7ecf\u63d0\u5230\u7684\uff0c\u8fc7\u53bb\u8bb8\u591a\u5ba2\u6237\u56e0\u4e3a\u590d\u6742\u7684\u7279\u6b8a\u6848\u4f8b\u800c\u627e\u5230\u6211\u4eec\u3002\u81ea 2020 \u5e74\u6211\u4eec\u4e0e Kymos \u5408\u5e76\u4ee5\u6765\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u5ba2\u6237\u4e5f\u5f00\u59cb\u8f6c\u5411\u6211\u4eec\u8fdb\u884c\u5927\u578b\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6211\u4eec\u73b0\u5728\u53ef\u4ee5\u5e38\u89c4\u4e14\u5feb\u901f\u5730\u5904\u7406\u8fd9\u4e9b\u8bd5\u9a8c\u3002\u4e0e\u5df4\u585e\u7f57\u90a3\u7684 Kymos \u548c\u5b89\u79d1\u7eb3\u7684 Pharmaprogress \u4e00\u8d77\uff0c\u6211\u4eec\u62e5\u6709\u4e09\u53f0 API-6500\uff08\u5176\u4e2d\u4e24\u53f0\u4e0e Agilent UHPLC \u8054\u7528\uff09\u3001\u4e24\u53f0\u8fde\u63a5\u5230 Waters UPLC Acquity \u7684\u9ad8\u7075\u654f\u5ea6 API 5500\u3001\u516d\u53f0 API-4000 \u548c\u4e00\u53f0 API-3200\uff08\u5747\u4e3a SCIEX \u4e09\u91cd\u56db\u6781\u6746\uff09\u3002\u6211\u4eec\u73b0\u5728\u6bcf\u6708\u80fd\u591f\u5904\u7406\u8d85\u8fc7 31,000 \u4e2a\u751f\u7269\u5206\u6790\u6837\u672c\u3002\u201d<\/span><\/p>\n

\n

\u9664\u4e86\u901a\u91cf\u80fd\u529b\u5916\uff0cProlytic \u4ecd\u51c6\u5907\u597d\u5e94\u5bf9\u6781\u5176\u590d\u6742\u7684\u4e3b\u9898\u3002Katrin Dorfmeyer \u63d0\u5230\u4e86\u6211\u4eec\u6700\u65b0\u7684\u9879\u76ee\uff1a\u201c\u5728\u6211\u4eec\u7531 BMBF \u8d44\u52a9\u7684\u7814\u7a76\u9879\u76ee\u4e2d\uff0c\u6211\u4eec\u6700\u8fd1\u6210\u529f\u5f00\u53d1\u4e86\u4e00\u79cd\u7528\u4e8e\u6d4b\u5b9a \u5c3f\u6db2\u4e2d\u524d\u5217\u817a\u7d20<\/strong> \u7684 LC-MS\/MS \u65b9\u6cd5\u3002\u7531\u4e8e\u524d\u5217\u817a\u7d20\u7684\u4e0d\u7a33\u5b9a\u6027\u548c\u96be\u4ee5\u8fdb\u884c\u7684\u8272\u8c31\u5206\u79bb\uff0c\u4f5c\u4e3a\u5185\u6e90\u6027\u6807\u5fd7\u7269\uff0c\u5176\u68c0\u6d4b\u6781\u5176\u590d\u6742\u3002\u901a\u8fc7\u7279\u6b8a\u7684\u56fa\u76f8\u8403\u53d6\u548c\u6211\u4eec\u56e2\u961f\u5f00\u53d1\u7684\u65b0\u6807\u51c6\u5316\u7a0b\u5e8f\uff0c\u6211\u4eec\u80fd\u591f\u6839\u636e GLP \u9a8c\u8bc1 LC-MS\/MS \u65b9\u6cd5\u3002\u201d <\/span><\/p>\n<\/blockquote>\n

\u201c\u8fd9\u4e9b\u79d1\u5b66\u6311\u6218\u6fc0\u52b1\u5e76\u542f\u53d1\u4e86\u6211\u548c\u6211\u7684\u56e2\u961f\u3002\u201d\u5979\u7ee7\u7eed\u8bf4\u9053\uff0c\u201c\u7136\u800c\uff0c\u540c\u6837\u4ee4\u4eba\u6ee1\u610f\u7684\u662f\uff0c\u5c31\u50cf macimorelin (Macrilen, Ghryvelin) \u7684\u60c5\u51b5\u4e00\u6837\uff0c\u6211\u4eec\u6709\u5e78\u53c2\u4e0e\u4e86\u4e00\u4e2a\u6700\u7ec8\u6210\u529f\u4e0a\u5e02\u7684\u9879\u76ee\uff0c\u5e76\u4e3a\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u505a\u51fa\u4e86\u8d21\u732e\u3002\u201d <\/span><\/p>\n

Aeterna Zentaris \u662f\u4e00\u5bb6\u4e13\u4e1a\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u591a\u6837\u5316\u7684\u836f\u7269\u548c\u8bca\u65ad\u4ea7\u54c1\u7ec4\u5408\uff0c\u4e13\u6ce8\u4e8e\u91cd\u5927\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u9886\u57df\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u5173\u4e8e Aeterna Zentaris \u53ca\u5176\u9879\u76ee\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee https:\/\/www.zentaris.com\/<\/a> \u6216\u901a\u8fc7 aezs@jtcir.com<\/a> \u4e0e\u4ed6\u4eec\u8054\u7cfb\u3002 <\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":42871,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[382,384],"tags":[62],"class_list":["post-42867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kymos-","category-384","tag-joan"],"acf":[],"yoast_head":"\nProlytic\/Kymos \u7684\u524d\u5217\u817a\u7d20\u751f\u7269\u5206\u6790<\/title>\n<meta name=\"description\" content=\"Prolytic \u62e5\u6709\u4e00\u79cd\u7ecf\u8fc7 GLP \u9a8c\u8bc1\u7684\u5c3f\u6db2\u4e2d\u524d\u5217\u817a\u7d20\u5b9a\u91cf\u65b9\u6cd5\u3002\u8054\u7cfb\u6211\u4eec\u4ee5\u83b7\u53d6\u66f4\u591a\u4fe1\u606f\u3002 info@prolytic.de\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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