{"id":42782,"date":"2020-09-28T10:11:26","date_gmt":"2020-09-28T08:11:26","guid":{"rendered":"https:\/\/kymos.com\/news\/kymos-%e4%b8%8e-prolytic-%e5%90%88%e5%b9%b6%e6%88%90%e7%ab%8b-kymos-group\/"},"modified":"2026-07-07T12:55:05","modified_gmt":"2026-07-07T10:55:05","slug":"kymos-%e4%b8%8e-prolytic-%e5%90%88%e5%b9%b6%e6%88%90%e7%ab%8b-kymos-group","status":"publish","type":"post","link":"https:\/\/kymos.com\/zh-hans\/news\/kymos-%e4%b8%8e-prolytic-%e5%90%88%e5%b9%b6%e6%88%90%e7%ab%8b-kymos-group\/","title":{"rendered":"Kymos \u4e0e Prolytic \u5408\u5e76\u6210\u7acb Kymos Group"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:calc( 1170px + 20px );margin-left: calc(-20px \/ 2 );margin-right: calc(-20px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:10px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:10px;--awb-width-medium:100%;--awb-spacing-right-medium:10px;--awb-spacing-left-medium:10px;--awb-width-small:100%;--awb-spacing-right-small:10px;--awb-spacing-left-small:10px;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><h3 class=\"\" style=\"--fontsize: 17; line-height: 1.67; --minfontsize: 17;\" data-fontsize=\"17\" data-lineheight=\"28.39px\"><span style=\"font-size: 14pt;\"><strong>\u968f\u7740\u8fd9\u5bb6\u5fb7\u56fd CRO \u52a0\u5165\u8be5\u6b27\u6d32\u96c6\u56e2\uff0cKymos \u5c06\u52a0\u5f3a\u5176\u5728\u751f\u7269\u5236\u836f\u548c\u5148\u8fdb\u7597\u6cd5\u5e02\u573a\u7684\u4e1a\u52a1\uff0c\u6269\u5927\u670d\u52a1\u7ec4\u5408\uff0c\u540c\u65f6\u5728\u6b27\u6d32\u63d0\u4f9b\u4e09\u4e2a\u672c\u5730\u7ad9\u70b9\u3002<\/strong><\/span><\/h3>\n<div class=\"blog-content\">\n<div class=\"field field-name-body field-type-text-with-summary field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p><span style=\"font-size: 14pt;\"><strong>\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u548c\u5fb7\u56fd\u6cd5\u5170\u514b\u798f\uff0c2020 \u5e74 9 \u6708 28 \u65e5<\/strong> \u2013 <a href=\"https:\/\/kymos.com\/zh-hans\/kymos\/\" data-wpel-link=\"internal\">Kymos S.L<\/a>. \u4e0e <a href=\"https:\/\/kymos.com\/zh-hans\/prolytic\/\" data-wpel-link=\"internal\">Prolytic GmbH<\/a> \u4eca\u65e5\u5ba3\u5e03\u5b8c\u6210\u6218\u7565\u5408\u5e76\uff0c\u5c06 Prolytic \u6574\u5408\u81f3 Kymos Group\uff0c\u65e8\u5728\u5feb\u901f\u53d8\u5316\u7684\u5546\u4e1a\u73af\u5883\u4e2d\uff0c\u901a\u8fc7\u771f\u6b63\u7684\u5168\u6b27\u89e3\u51b3\u65b9\u6848\u4e3a\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u63d0\u4f9b\u589e\u503c\u670d\u52a1\u3002 <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u4e13\u4e1a\u77e5\u8bc6\u7684\u7ed3\u5408\u5c06\u4f7f\u4e24\u5bb6\u516c\u53f8\u80fd\u591f\u5c06\u5176\u670d\u52a1\u7ec4\u5408\u6269\u5c55\u5230\u72ec\u7279\u7684\u9886\u57df\uff0c\u6db5\u76d6\u521b\u65b0\u7684\u5c0f\u5206\u5b50\u548c\u5927\u5206\u5b50\u3001\u4eff\u5236\u836f\u3001\u751f\u7269\u7c7b\u4f3c\u836f\u3001\u6297\u4f53\u3001\u751f\u7269\u6807\u5fd7\u7269\u3001ADA\uff08\u6297\u836f\u7269\u6297\u4f53\uff09\u3001ADC\uff08\u6297\u4f53\u5076\u8054\u836f\u7269\uff09\u3001\u6fc0\u7d20\u3001\u9176\u548c\u6838\u9178\u3002\u4ed6\u4eec\u8fd8\u5c06\u52a0\u5f3a\u5728\u5148\u8fdb\u7597\u6cd5\u5e02\u573a\u7684\u6d3b\u52a8\u3002\u76ee\u524d\uff0c\u6b27\u6d32\u53ca\u5168\u7403\u5bf9\u91cd\u7ec4\u86cb\u767d\u4ee5\u53ca\u5148\u8fdb\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u7684\u5174\u8da3\u6b63\u5904\u4e8e\u84ec\u52c3\u53d1\u5c55\u9636\u6bb5\u3002Prolytic \u5728 mRNA \u6280\u672f\u65b9\u9762\u79ef\u7d2f\u4e86\u4e13\u4e1a\u77e5\u8bc6\uff0c\u8be5\u6280\u672f\u6b63\u7528\u4e8e\u6b27\u6d32\u6b63\u5728\u5f00\u53d1\u7684\u4e00\u4e9b\u6700\u5148\u8fdb\u7684 Covid-19 \u75ab\u82d7\u4e2d\u3002   <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u8fd9\u4e24\u5bb6\u516c\u53f8\u4e0e Kymos Group \u5728\u610f\u5927\u5229\u7684\u5b50\u516c\u53f8 Pharmaprogress \u4e00\u6837\uff0c\u90fd\u81f4\u529b\u4e8e\u8d28\u91cf\u548c\u521b\u65b0\u3002\u5ba2\u6237\u5728\u83b7\u5f97\u66f4\u5e7f\u6cdb\u7684 GMP\/GLP \u8ba4\u8bc1\u548c\u7b26\u5408 GCP \u6807\u51c6\u7684\u670d\u52a1\u7684\u540c\u65f6\uff0c\u4ecd\u5c06\u83b7\u5f97\u5728\u5176\u4ed6\u540c\u7b49\u89c4\u6a21\u7684 CRO \u4e2d\u5c11\u89c1\u7684\u91cf\u8eab\u5b9a\u5236\u3001\u4e2a\u6027\u5316\u4e14\u6781\u5177\u7075\u6d3b\u6027\u7684\u670d\u52a1\u3002Kymos \u548c Prolytic \u5bf9\u4ece\u5f00\u53d1\u548c\u4e34\u5e8a\u9636\u6bb5\u5230\u6700\u7ec8\u6279\u51c6\u53ca\u4e0a\u5e02\u540e\u7814\u7a76\u7684\u6574\u4e2a\u836f\u7269\u5f00\u53d1\u548c\u5236\u9020\u8fc7\u7a0b\u5177\u6709\u591a\u5b66\u79d1\u7684\u7406\u89e3\uff0c\u63d0\u4f9b\u7269\u6d41\u5b89\u5168\u6027\u548c\u53ef\u9760\u6027\u3002\u6b64\u6b21\u5408\u5e76\u5c06\u63d0\u9ad8\u516c\u53f8\u5bf9\u5168\u7403\u5ba2\u6237\u7279\u5b9a\u9700\u6c42\u505a\u51fa\u66f4\u5feb\u53cd\u5e94\u7684\u80fd\u529b\u3002   <\/span><\/p>\n<p><span style=\"font-size: 14pt;\"><em>\u201c\u5f53\u4eca\u5e02\u573a\u9700\u8981\u5168\u65b9\u4f4d\u670d\u52a1\u63d0\u4f9b\u5546\u548c\u4e00\u7ad9\u5f0f\u89e3\u51b3\u65b9\u6848\u3002\u901a\u8fc7\u8fd9\u6b21\u5408\u5e76\uff0c\u6211\u4eec\u5c06\u80fd\u591f\u5b9e\u73b0\u5168\u7403\u5316\u601d\u8003\u3001\u672c\u5730\u5316\u884c\u52a8\uff0c\u4e3a\u6211\u4eec\u7684\u5ba2\u6237\u63d0\u4f9b\u53ef\u9760\u3001\u503c\u5f97\u4fe1\u8d56\u4e14\u5927\u5e45\u6539\u8fdb\u7684\u670d\u52a1\uff0c\u201d<\/em> Prolytic \u603b\u7ecf\u7406 Dorothee Krone \u535a\u58eb\u8868\u793a\u3002<em>\u201c\u4e2d\u5c0f\u578b\u516c\u53f8\u5bf9\u4e0e\u6211\u4eec\u5408\u4f5c\u611f\u5230\u5f88\u8212\u5fc3\u3002Kymos \u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u8986\u76d6\u6574\u4e2a\u751f\u547d\u79d1\u5b66\u5468\u671f\uff0c\u6211\u4eec\u73b0\u5728\u53ef\u4ee5\u63d0\u4f9b\u6bd4\u8fc7\u53bb\u66f4\u591a\u6837\u5316\u7684\u670d\u52a1\u3002\u201d<\/em><\/span><\/p>\n<p><span style=\"font-size: 14pt;\"><em>\u201cProlytic \u5728 DNA \u548c RNA \u65b9\u9762\u7684\u77e5\u8bc6\u662f Kymos \u6b63\u5728\u8fdb\u5165\u7684\u5148\u8fdb\u7597\u6cd5\u670d\u52a1\u5e02\u573a\u7684\u5173\u952e\u79d1\u5b66\u8981\u7d20\uff0c\u201d<\/em> Kymos \u9996\u5e2d\u6267\u884c\u5b98 Joan Puig de Dou \u5148\u751f\u8868\u793a\u3002<em>\u201c\u6b64\u6b21\u5408\u5e76\u8ba9\u6211\u4eec\u6709\u673a\u4f1a\u589e\u52a0\u670d\u52a1\u9879\u76ee\uff0c\u52a0\u5f3a\u65b0\u5174\u7597\u6cd5\u5e02\u573a\uff0c\u5e76\u521b\u5efa\u4e00\u5bb6\u8de8\u56fd\u3001\u591a\u5b66\u79d1\u7684\u516c\u53f8\u3002\u6211\u4eec\u975e\u5e38\u671f\u5f85\u516c\u53f8\u5386\u53f2\u4e0a\u7684\u8fd9\u4e00\u65b0\u9636\u6bb5\u3002\u201d<\/em><\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u901a\u8fc7\u6b64\u6b21\u5408\u5e76\uff0cKymos \u76ee\u524d\u5728\u6b27\u6d32\u62e5\u6709\u4e09\u4e2a\u7ad9\u70b9\uff1a\u5206\u522b\u4f4d\u4e8e\u5df4\u585e\u7f57\u90a3\uff08\u897f\u73ed\u7259\uff09\u3001\u5b89\u79d1\u7eb3\uff08\u610f\u5927\u5229\uff09\u548c\u6cd5\u5170\u514b\u798f\uff08\u5fb7\u56fd\uff09\u3002\u610f\u5927\u5229\u7ad9\u70b9\u662f 2016 \u5e74\u4e0e Pharmaprogress SRL \u5408\u5e76\u7684\u7ed3\u679c\u3002\u6839\u636e\u534f\u8bae\uff0c\u516c\u53f8\u540d\u79f0\u5c06\u4fdd\u6301\u4e0d\u53d8\u3002\u5728 Prolytic \u7684\u5fb7\u56fd\u7ad9\u70b9\uff0c\u73b0\u6709\u7ba1\u7406\u5c42\u5c06\u7559\u4efb\uff0c\u540c\u65f6\u5458\u5de5\u4eba\u6570\u5c06\u589e\u52a0\u3002\u516c\u53f8\u5c06\u5b9e\u65bd\u4e00\u9879\u6295\u8d44\u8ba1\u5212\uff0c\u4ee5\u8d2d\u7f6e\u6700\u5148\u8fdb\u7684\u8bbe\u5907\u3002    <\/span><\/p>\n<p><span style=\"font-size: 14pt;\">\u5728\u52a0\u5f3a\u5176\u5728\u6b27\u76df\u5df2\u6709\u7684\u663e\u8457\u5730\u4f4d\u540e\uff0c\u8be5\u6b27\u6d32\u96c6\u56e2\u5c06\u76ee\u6807\u8f6c\u5411\u6269\u5c55\u81f3\u4e9a\u592a\u5730\u533a\uff0c\u540c\u65f6\u5f00\u62d3\u6781\u5177\u524d\u666f\u7684\u65b0\u6cbb\u7597\u9886\u57df\u3002<\/span><\/p>\n<p><strong style=\"font-size: 14pt; color: var(--body_typography-color); font-family: var(--body_typography-font-family); font-style: var(--body_typography-font-style,normal); letter-spacing: var(--body_typography-letter-spacing);\">\u5173\u4e8e Prolytic  <\/strong><\/p>\n<p><span style=\"font-size: 14pt;\">Prolytic GmbH \u662f\u751f\u7269\u5206\u6790\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u9886\u57df\u7684\u4e13\u5bb6\uff0c\u62e5\u6709\u5728 GLP \u548c GCP \u6761\u4ef6\u4e0b\u8fdb\u884c\u751f\u7269\u5206\u6790\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u8bc4\u4f30\u7684\u4e13\u4e1a\u5408\u540c\u7814\u7a76\u80fd\u529b\u3002<\/span><br \/><span style=\"font-size: 14pt;\">\u5b83\u5728\u5f00\u53d1\u548c\u9a8c\u8bc1\u5206\u6790\u65b9\u6cd5\u65b9\u9762\u63d0\u4f9b\u4e00\u7cfb\u5217\u5c16\u7aef\u670d\u52a1\uff0c\u7528\u4e8e\u5c0f\u5206\u5b50\u3001\u86cb\u767d\u8d28\u3001\u6297\u4f53\u548c\u6297\u539f\u3001ADA\uff08\u6297\u836f\u7269\u6297\u4f53\uff09\u3001\u751f\u7269\u6807\u5fd7\u7269\u548c\u751f\u7269\u7c7b\u4f3c\u836f\u4ee5\u53ca\u5b8c\u6574\u9176\u7684\u5206\u6790\u548c\u5b9a\u91cf\uff0c\u5e76\u4e3a\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u6837\u672c\u5206\u6790\u3002Prolytic \u53ef\u4ee5\u5bf9\u8840\u6db2\u3001\u8840\u6d46\u3001\u5c3f\u6db2\u3001\u7ec4\u7ec7\u6216\u5176\u4ed6\u751f\u7269\u57fa\u8d28\u8fdb\u884c\u5b9a\u6027\u6216\u5b9a\u91cf\u836f\u7269\u53ca\u4ee3\u8c22\u7269\u5206\u6790\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u53ef\u4ee5\u8fdb\u884c\u623f\u5ba4\u548c\u975e\u623f\u5ba4\u836f\u4ee3\u52a8\u529b\u5b66\u8bc4\u4f30\u3002\u4f5c\u4e3a\u521b\u65b0\u8005\uff0cProlytic \u662f RNA \u751f\u7269\u6807\u5fd7\u7269\u5f00\u53d1\u548c\u5148\u8fdb\u7597\u6cd5\u9886\u57df\u653f\u5e9c\u8d44\u52a9\u7814\u7a76\u5408\u4f5c\u9879\u76ee\u7684\u9886\u5bfc\u8005\u3002   <\/span><br \/><span style=\"font-size: 14pt;\">Prolytic \u6210\u7acb\u4e8e 2002 \u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u6cd5\u5170\u514b\u798f\uff0c\u62e5\u6709 17 \u540d\u5458\u5de5\u548c 1,000 \u5e73\u65b9\u7c73\u7684\u6700\u5148\u8fdb\u4eea\u5668\u8bbe\u65bd\u3002<\/span><\/p>\n<p><span style=\"font-size: 18.6667px;\"><a href=\"https:\/\/kymos.com\/zh-hans\/prolytic\/\" data-wpel-link=\"internal\">kymos.com\/prolytic<\/a><\/span><\/p>\n<p><span style=\"font-size: 14pt;\"><strong>\u5173\u4e8e Kymos<\/strong><\/span><br \/><span style=\"font-size: 14pt;\">Kymos S.L. \u662f\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u68c0\u6d4b\u670d\u52a1\u4f9b\u5e94\u5546\u4e4b\u4e00\uff0c\u5728\u751f\u7269\u5236\u836f\u3001\u5c0f\u5206\u5b50\u4ee5\u53ca CMC \u548c\u751f\u7269\u5206\u6790\u7684\u5168\u65b9\u4f4d\u670d\u52a1\u65b9\u9762\u62e5\u6709\u591a\u5e74\u7ecf\u9a8c\u3002\u4f5c\u4e3a\u4e00\u5bb6\u901a\u8fc7 GLP\/GMP \u8ba4\u8bc1\u3001\u7b26\u5408 GCP \u6807\u51c6\u3001\u5e76\u7ecf\u8fc7 EMA \u548c FDA \u68c0\u67e5\u7684\u6b27\u6d32\u5408\u540c\u5b9e\u9a8c\u5ba4\u7ec4\u7ec7\uff0cKymos \u4e13\u6ce8\u4e8e\u751f\u7269\u5206\u6790\u548c CMC\uff0c\u63d0\u4f9b\u5b8c\u6574\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff0c\u5305\u62ec\u5c40\u90e8\u5236\u5242\uff08DP\uff09\u7684\u751f\u7269\u8c41\u514d\u3001\u5927\u5c0f\u5206\u5b50\u751f\u7269\u5206\u6790\u3001ADA\uff0c\u4ee5\u53ca\u6b27\u6d32\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6279\u6b21\u653e\u884c\u68c0\u6d4b\u3002Kymos \u8fd8\u63d0\u4f9b\u65b9\u6cd5\u5f00\u53d1\u3001\u8868\u5f81\u3001\u751f\u7269\u7c7b\u4f3c\u836f\u53ef\u6bd4\u6027\u7b49 CMC \u670d\u52a1\uff0c\u5e76\u62e5\u6709\u591a\u5e74\u670d\u52a1\u5168\u7403\u751f\u7269\u5236\u836f\u5ba2\u6237\u7684\u7ecf\u9a8c\u3002  <\/span><br \/><span style=\"font-size: 14pt;\">Kymos \u6210\u7acb\u4e8e 2001 \u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u5df4\u585e\u7f57\u90a3\uff0c\u62e5\u6709 110 \u540d\u5458\u5de5\u548c 3,000 \u5e73\u65b9\u7c73\u7684\u8bbe\u65bd\uff0c\u914d\u5907\u9876\u7ea7\u4eea\u5668\u3002\u610f\u5927\u5229\u5b50\u516c\u53f8\u53e6\u6709 20 \u540d\u5458\u5de5\u548c\u7ea6 1,000 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Dou","image":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/secure.gravatar.com\/avatar\/263d7ff1c7891f5821a5075a1a362a1e513db5931dc882455e887fe1c1ccf924?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/263d7ff1c7891f5821a5075a1a362a1e513db5931dc882455e887fe1c1ccf924?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/263d7ff1c7891f5821a5075a1a362a1e513db5931dc882455e887fe1c1ccf924?s=96&d=mm&r=g","caption":"Joan Puig de Dou"},"description":"Active in the pharmaceutical marketing for over 30 years President of CataloniaBIO&amp;HealthTech CEO and Qualified Person at Kymos Leader of Kymos team, guaranteeing a trustable, ethical and scientific correct editorial publications. Experience Joan Puig de Dou started his career at Laboratorios Menarini first as scientist later as Qualified Person and finally as Operations General Manager. 2010 he entered Kymos where he became CEO in 2015. 2022 Joan Puig de Dou was elected as president of CataloniaBio&amp;HealthTech to represent the Catalonian biotech industry nationally and internationally. Expertise Joan Puig de Dou has extensive experience in writing scientific content adopting a didactic approach that fits any reader\u2019s level of expertise. He publishes regularely on Kymos\u2019 webpage, social media and in the specialized press. Education He graduated from Universitat de Barcelona as Pharmacist and from IESE Business School\u2019s Programa Diecci\u00f3n General (PDG) Want to know him better? Read his interview in PharmaBoardrooom in January 2019 and more about his presidency of CataloniaBio at Parc Sc\u00edentific de Barcelona.","url":"https:\/\/kymos.com\/zh-hans\/news\/author\/joan-puig-de-dou\/"}]}},"_links":{"self":[{"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/posts\/42782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=42782"}],"version-history":[{"count":2,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/posts\/42782\/revisions"}],"predecessor-version":[{"id":42785,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/posts\/42782\/revisions\/42785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/media\/42783"}],"wp:attachment":[{"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=42782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=42782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kymos.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=42782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}