{"id":42276,"date":"2025-11-05T08:04:26","date_gmt":"2025-11-05T07:04:26","guid":{"rendered":"https:\/\/kymos.com\/%e5%af%a1%e6%a0%b8%e8%8b%b7%e9%85%b8%e8%b4%a8%e9%87%8f%e6%8e%a7%e5%88%b6\/"},"modified":"2026-07-12T09:43:49","modified_gmt":"2026-07-12T07:43:49","slug":"%e5%af%a1%e6%a0%b8%e8%8b%b7%e9%85%b8%e8%b4%a8%e9%87%8f%e6%8e%a7%e5%88%b6","status":"publish","type":"page","link":"https:\/\/kymos.com\/zh-hans\/%e6%9c%8d%e5%8a%a1%e9%a1%b9%e7%9b%ae\/cmc-%e5%88%86%e6%9e%90%e4%b8%8e%e8%b4%a8%e9%87%8f%e6%8e%a7%e5%88%b6\/%e5%af%a1%e6%a0%b8%e8%8b%b7%e9%85%b8%e8%b4%a8%e9%87%8f%e6%8e%a7%e5%88%b6\/","title":{"rendered":"\u5be1\u6838\u82f7\u9178\u8d28\u91cf\u63a7\u5236"},"content":{"rendered":"

\u5be1\u6838\u82f7\u9178\u8d28\u91cf\u63a7\u5236<\/h1><\/div>

GMP \u6761\u4ef6\u4e0b\u5408\u6210\u5be1\u6838\u82f7\u9178\u7684\u5168\u9762 CMC \u68c0\u6d4b<\/p>\n<\/div>

\u54a8\u8be2\u4e13\u5bb6<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div>

\u57fa\u4e8e\u5be1\u6838\u82f7\u9178\u7684\u836f\u7269\u6b63\u5728\u6539\u53d8\u73b0\u4ee3\u533b\u5b66\uff0c\u4e3a\u9057\u4f20\u75c5\u548c\u7f55\u89c1\u75c5\u63d0\u4f9b\u9776\u5411\u6cbb\u7597\uff0c\u4f46\u5176\u590d\u6742\u7684\u5316\u5b66\u6027\u8d28\u5e26\u6765\u4e86\u65b0\u7684\u5206\u6790\u6311\u6218\u548c\u76d1\u7ba1\u9884\u671f\u3002<\/p>\n

\u5728 Kymos \u96c6\u56e2\uff0c\u6211\u4eec\u4e3a\u5408\u6210\u5be1\u6838\u82f7\u9178\u63d0\u4f9b\u5168\u9762\u7684\u8d28\u91cf\u63a7\u5236\u548c CMC \u5206\u6790\u670d\u52a1\uff0c\u652f\u6301\u5ba2\u6237\u4ece\u65e9\u671f\u5f00\u53d1\u5230 GMP \u653e\u884c\u6d4b\u8bd5\u3002<\/p>\n

\u8fd9\u4e9b\u670d\u52a1\u5efa\u7acb\u5728 OligoXplorer \u671f\u95f4\u5f00\u53d1\u7684\u5206\u6790\u65b9\u6cd5\u57fa\u7840\u4e4b\u4e0a\uff0cOligoXplorer \u662f\u6211\u4eec\u5185\u90e8\u7684\u4e00\u9879\u7814\u7a76\u8ba1\u5212\uff0c\u81f4\u529b\u4e8e\u63a8\u8fdb\u5be1\u6838\u82f7\u9178\u8868\u5f81\uff0c\u76ee\u524d\u8fd9\u4e9b\u65b9\u6cd5\u5df2\u901a\u8fc7\u5168\u9762\u9a8c\u8bc1\u5e76\u53ef\u4f9b\u884c\u4e1a\u5408\u4f5c\u4f19\u4f34\u4f7f\u7528\u3002<\/p>\n<\/div><\/div><\/div>

\"Raw<\/div><\/div><\/div><\/div>
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\u670d\u52a1<\/p>\n<\/div>

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\u6211\u4eec\u7684\u5206\u6790\u80fd\u529b<\/h2><\/div><\/div><\/div>
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 <\/p>\n\n\n\n\n\n\n\n\n\n\n
\u8d28\u91cf\u5c5e\u6027<\/strong><\/span><\/th>\n\u53c2\u6570<\/strong><\/span><\/th>\n\u6280\u672f<\/strong><\/span><\/th>\n<\/tr>\n<\/thead>\n
\u6548\u4ef7<\/strong><\/span><\/td>\n\u542b\u91cf\u6d4b\u5b9a\u3001LNP \u4e2d\u7684\u8102\u8d28\u542b\u91cf<\/td>\n\u79bb\u5b50\u5bf9-HPLC-UV-MS\u3001HPLC-CAD<\/td>\n<\/tr>\n
\u9274\u522b<\/strong><\/span><\/td>\n\u5e8f\u5217\u3001\u5206\u5b50\u91cf\u3001\u5316\u5b66\u7ed3\u6784\u3001\u8102\u8d28<\/td>\n\u79bb\u5b50\u5bf9-HPLC-UV-MS\u3001AEX (SAX)-HPLC\u3001NMR\u3001HPLC-CAD\u3001DLS<\/td>\n<\/tr>\n
\u7eaf\u5ea6<\/strong><\/span><\/td>\n\u805a\u96c6\u3001\u4ea7\u54c1\u76f8\u5173\u6742\u8d28\u3001\u6b8b\u7559\u6eb6\u5242\u3001\u4e59\u9178\u76d0\u3001\u6c34\u5206\u542b\u91cf\u3001\u5143\u7d20\u6742\u8d28<\/td>\nSEC-HPLC\u3001DLS\u3001\u79bb\u5b50\u5bf9-HPLC-UV\u3001AEX (SAX)-HPLC\u3001HS-GC\u3001KF\u3001\u79bb\u5b50 HPLC\u3001ICP-MS<\/td>\n<\/tr>\n
\u5b89\u5168\u6027<\/strong><\/span><\/td>\n\u5fae\u751f\u7269\u9650\u5ea6 (TAMC\/TYMC)\u3001\u5185\u6bd2\u7d20\u3001\u65e0\u83cc<\/td>\n\u5fae\u751f\u7269\u6280\u672f<\/td>\n<\/tr>\n
\u5305\u88c5<\/strong><\/span><\/td>\n\u53ef\u63d0\u53d6\u7269\u4e0e\u6d78\u51fa\u7269\u3001\u5bb9\u5668\u5bc6\u5c01\u5b8c\u6574\u6027<\/td>\nGC\/MS\u3001LC\/HRMS (Orbitrap)\u3001HPLC\/UPLC MS\u3001LC\/UV-vis\u3001\u8272\u8c31\u6cd5<\/td>\n<\/tr>\n
\u836f\u5178\u9879\u76ee<\/strong><\/span><\/td>\n\u5916\u89c2\u3001\u6e17\u900f\u538b\u3001\u9897\u7c92\u7269\u3001pH \u503c\u3001\u53ef\u63d0\u53d6\u4f53\u79ef<\/td>\n\u6807\u51c6\u6280\u672f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div><\/div><\/div>
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\u670d\u52a1<\/p>\n<\/div>

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\u6211\u4eec\u7684\u5b8c\u6574\u89e3\u51b3\u65b9\u6848<\/h2><\/div><\/div><\/div>
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\"Identity<\/div><\/div>

\u9274\u522b\u4e0e\u7ed3\u6784<\/h3><\/h1><\/div>