{"id":27133,"date":"2018-07-07T13:25:50","date_gmt":"2018-07-07T11:25:50","guid":{"rendered":"https:\/\/kymos.com\/news\/tests-dactivite-anti-facteur-de-lheparine\/"},"modified":"2018-07-07T13:25:50","modified_gmt":"2018-07-07T11:25:50","slug":"tests-dactivite-anti-facteur-de-lheparine","status":"publish","type":"post","link":"https:\/\/kymos.com\/fr\/news\/tests-dactivite-anti-facteur-de-lheparine\/","title":{"rendered":"Tests d’activit\u00e9 anti-facteur de l’h\u00e9parine"},"content":{"rendered":"

L’h\u00e9parine<\/strong> est un glycosaminoglycane sulfat\u00e9 pr\u00e9sent sous forme d’un m\u00e9lange de mol\u00e9cules h\u00e9t\u00e9rog\u00e8nes de masses mol\u00e9culaires variables, utilis\u00e9 en m\u00e9decine comme anticoagulant. On la trouve dans les tissus des mammif\u00e8res et elle est g\u00e9n\u00e9ralement extraite de la muqueuse intestinale ou d’autres tissus appropri\u00e9s de mammif\u00e8res domestiques destin\u00e9s \u00e0 l’alimentation humaine. Elle est purifi\u00e9e afin de conserver une combinaison d’activit\u00e9s contre les diff\u00e9rentes \u00e9tapes de la coagulation sanguine. Elle est compos\u00e9e de polym\u00e8res de d\u00e9riv\u00e9s altern\u00e9s de D-glucosamine (N-sulfat\u00e9, O-sulfat\u00e9 ou N-ac\u00e9tyl\u00e9) et d’acide uronique (acide L-iduronique ou acide D-glucuronique) li\u00e9s par des liaisons glycosidiques. Le fractionnement des h\u00e9parines permet d’obtenir des h\u00e9parines de bas poids mol\u00e9culaire (HBPM) qui pr\u00e9sentent certains avantages par rapport aux h\u00e9parines non fractionn\u00e9es. <\/span><\/p>\n

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<\/h3>\n

Histoire r\u00e9cente<\/span><\/h3>\n

En r\u00e9ponse \u00e0 la crise de falsification de l’h\u00e9parine de 2007\/2008, qui a caus\u00e9 au moins 81 d\u00e9c\u00e8s aux \u00c9tats-Unis suite \u00e0 la contamination de la mati\u00e8re premi\u00e8re fabriqu\u00e9e en Chine par du sulfate de chondro\u00eftine sursulfat\u00e9<\/b> (OSCS), les pharmacop\u00e9es am\u00e9ricaine et europ\u00e9enne ont r\u00e9vis\u00e9 leurs monographies sur l’h\u00e9parine .<\/b> Les monographies USP32-NF27 et Ph Eur. Ed. 7e \u00e9dition<\/g> ont int\u00e9gr\u00e9 l’application de techniques analytiques orthogonales telles que la RMN du proton (\u00b9H<\/g> -RMN)<\/g> , la chromatographie d’\u00e9change d’anions<\/g> et l’\u00e9lectrophor\u00e8se capillaire<\/g> afin de confirmer l’absence d’OSCS. De plus, le test de coagulation pr\u00e9c\u00e9demment r\u00e9alis\u00e9 sur plasma de mouton a \u00e9t\u00e9 remplac\u00e9 par des tests plus sp\u00e9cifiques d’ activit\u00e9 anti-facteur IIa<\/strong> et anti-facteur Xa<\/strong> . <\/span><\/p>\n

<\/h3>\n

Base scientifique du test<\/span><\/h3>\n

Le facteur Xa et le facteur IIa (ou thrombine) sont des prot\u00e9ines hydrolytiques (ou peptidases) qui interviennent dans la voie finale commune de la cascade de coagulation. Le facteur Xa catalyse la transformation de la prothrombine en facteur II. Le facteur II, quant \u00e0 lui, catalyse la conversion du fibrinog\u00e8ne soluble en fibrine insoluble, constituant ainsi le tissu fibrineux. <\/span><\/p>\n

Prothrombine + Facteur Xa \u2192 Facteur IIa<\/b><\/span><\/p>\n

Fibrinog\u00e8ne + Facteur IIa \u2192 Fibrine (tissu) <\/b><\/span><\/p>\n

L’activit\u00e9 des facteurs IIa et Xa est inhib\u00e9e par l’antithrombine (AT), modulant ainsi la cascade de coagulation : une augmentation de l’activit\u00e9 de l’AT entra\u00eene une diminution de la coagulation et inversement. L’h\u00e9parine se lie \u00e0 l’AT, induisant un changement conformationnel qui renforce son effet inhibiteur sur les facteurs IIa et Xa. Cette potentialisation de l’inhibition de ces peptidases est \u00e0 l’origine de l’effet anticoagulant des h\u00e9parines lors de leur utilisation pharmacologique. Les h\u00e9parines de bas poids mol\u00e9culaire catalysent moins facilement la r\u00e9action entre le facteur IIa et l’antithrombine que celle impliquant le facteur Xa<\/b> . En revanche, l’h\u00e9parine non fractionn\u00e9e catalyse les deux r\u00e9actions de mani\u00e8re \u00e9quivalente. <\/span><\/p>\n

<\/h3>\n

Contribution de Kymos<\/span><\/h3>\n

Les kits disponibles dans le commerce ne constituent pas toujours une solution optimale et peuvent n\u00e9cessiter des am\u00e9liorations en fonction de l’origine, de la concentration et des contaminants de l’h\u00e9parine, ainsi que d’autres facteurs. La mise en \u0153uvre des tests de la Pharmacop\u00e9e est \u00e9galement complexe, m\u00eame pour les laboratoires exp\u00e9riment\u00e9s, et une validation de la m\u00e9thode est recommand\u00e9e. Kymos a d\u00e9velopp\u00e9 et valid\u00e9 les m\u00e9thodes de la Pharmacop\u00e9e europ\u00e9enne et de l’USP et propose des services d’analyse conformes aux BPF. D\u00e9couvrez nos services BPF pour les produits biologiques et biosimilaires<\/a> . <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

L’h\u00e9parine est un glycosaminoglycane sulfat\u00e9 pr\u00e9sent sous forme d’un m\u00e9lange […]<\/p>\n","protected":false},"author":7,"featured_media":27135,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[267],"tags":[],"class_list":["post-27133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cmc"],"acf":[],"yoast_head":"\nTest d'activit\u00e9 anti-facteur de l'h\u00e9parine - Kymos<\/title>\n<meta name=\"description\" content=\"Tests d'activit\u00e9 anti-facteur de l'h\u00e9parine r\u00e9alis\u00e9s selon une m\u00e9thode valid\u00e9e chez Kymosa, conform\u00e9ment \u00e0 la Pharmacop\u00e9e europ\u00e9enne et \u00e0 l'USP, dans le respect des BPF.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kymos.com\/fr\/news\/tests-dactivite-anti-facteur-de-lheparine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Test d'activit\u00e9 anti-facteur de l'h\u00e9parine - 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