{"id":24734,"date":"2025-11-05T08:04:26","date_gmt":"2025-11-05T07:04:26","guid":{"rendered":"https:\/\/kymos.com\/controle-de-la-qualite-des-oligonucleotides\/"},"modified":"2026-03-18T10:02:41","modified_gmt":"2026-03-18T09:02:41","slug":"controle-de-la-qualite-des-oligonucleotides","status":"publish","type":"page","link":"https:\/\/kymos.com\/fr\/services\/analyse-cmc-et-controle-qualite\/controle-de-la-qualite-des-oligonucleotides\/","title":{"rendered":"Contr\u00f4le qualit\u00e9 des oligonucl\u00e9otides"},"content":{"rendered":"

Contr\u00f4le qualit\u00e9 des oligonucl\u00e9otides<\/h1><\/div>

Tests CMC complets pour les oligonucl\u00e9otides synth\u00e9tiques dans des conditions BPF<\/p>\n<\/div>

Parler \u00e0 un expert<\/span><\/i><\/a><\/div><\/div><\/div><\/div><\/div>

Les m\u00e9dicaments \u00e0 base d\u2019oligonucl\u00e9otides transforment la m\u00e9decine moderne, offrant des traitements cibl\u00e9s pour les maladies g\u00e9n\u00e9tiques et rares, mais leur chimie complexe apporte de nouveaux d\u00e9fis analytiques et des attentes r\u00e9glementaires.<\/p>\n

Chez Kymos Group, nous fournissons une suite compl\u00e8te de services analytiques de contr\u00f4le qualit\u00e9 et CMC pour les oligonucl\u00e9otides synth\u00e9tiques, accompagnant nos clients du d\u00e9veloppement pr\u00e9coce aux tests de lib\u00e9ration BPF.<\/p>\n

Ces services s\u2019appuient sur les m\u00e9thodes analytiques d\u00e9velopp\u00e9es au cours d\u2019OligoXplorer, notre initiative de recherche interne d\u00e9di\u00e9e \u00e0 l\u2019avancement de la caract\u00e9risation des oligonucl\u00e9otides, et sont d\u00e9sormais enti\u00e8rement valid\u00e9s et mis \u00e0 la disposition des partenaires industriels.<\/p>\n<\/div><\/div><\/div>

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SERVICES<\/p>\n<\/div>

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Nos capacit\u00e9s analytiques<\/h2><\/div><\/div><\/div>
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Attribut de qualit\u00e9<\/strong><\/span><\/th>\nParam\u00e8tres<\/strong><\/span><\/th>\nTechniques<\/strong><\/span><\/th>\n<\/tr>\n<\/thead>\n
Concentration<\/strong><\/span><\/td>\nDosage, teneur en lipides dans les LNP<\/td>\nPaire d\u2019ions-HPLC-UV-MS, HPLC-CAD<\/td>\n<\/tr>\n
Identit\u00e9<\/strong><\/span><\/td>\nS\u00e9quence, poids mol\u00e9culaire, structure chimique, lipides<\/td>\nPaire d\u2019ions-HPLC-UV-MS, AEX (SAX)-HPLC, RMN, HPLC-CAD, DLS<\/td>\n<\/tr>\n
Puret\u00e9<\/strong><\/span><\/td>\nAgr\u00e9gation, impuret\u00e9s li\u00e9es au produit, solvants r\u00e9siduels, ac\u00e9tate, teneur en eau, impuret\u00e9s \u00e9l\u00e9mentaires<\/td>\nSEC-HPLC, DLS, Paire d\u2019ions-HPLC-UV, AEX (SAX)-HPLC, HS-GC, KF, HPLC ionique, ICP-MS<\/td>\n<\/tr>\n
S\u00e9curit\u00e9<\/strong><\/span><\/td>\nBiocharge (TAMC\/TYMC), endotoxines, st\u00e9rilit\u00e9<\/td>\nTechniques de microbiologie<\/td>\n<\/tr>\n
Emballage<\/strong><\/span><\/td>\nSubstances extractibles et lixiviables, int\u00e9grit\u00e9 de la fermeture du r\u00e9cipient<\/td>\nGC\/MS, LC\/HRMS (Orbitrap), HPLC\/UPLC MS, LC\/UV-vis, P\u00e9n\u00e9tration de colorant<\/td>\n<\/tr>\n
Pharmacop\u00e9e<\/strong><\/span><\/td>\nApparence, osmolarit\u00e9, particules, pH, volume extractible<\/td>\nTechniques standard<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div><\/div><\/div>
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SERVICES<\/p>\n<\/div>

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Notre solution compl\u00e8te<\/h2><\/div><\/div><\/div>
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\"Identity<\/div><\/div>

Identit\u00e9 et structure<\/h3><\/h1><\/div>