{"id":22756,"date":"2022-03-22T14:05:45","date_gmt":"2022-03-22T13:05:45","guid":{"rendered":"https:\/\/kymos.com\/news\/prolytic-i-aeterna-zentaris-20-anys-millorant-la-salut-humana-junts\/"},"modified":"2025-08-07T09:43:27","modified_gmt":"2025-08-07T07:43:27","slug":"prolytic-i-aeterna-zentaris-20-anys-millorant-la-salut-humana-junts","status":"publish","type":"post","link":"https:\/\/kymos.com\/ca\/news\/prolytic-i-aeterna-zentaris-20-anys-millorant-la-salut-humana-junts\/","title":{"rendered":"Prolytic i Aeterna Zentaris: 20 anys millorant la salut humana junts"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:calc( 1170px + 20px );margin-left: calc(-20px \/ 2 );margin-right: calc(-20px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:10px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:10px;--awb-width-medium:100%;--awb-spacing-right-medium:10px;--awb-spacing-left-medium:10px;--awb-width-small:100%;--awb-spacing-right-small:10px;--awb-spacing-left-small:10px;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><span style=\"font-size: 14pt;\">For almost 20 years, Kymos\u2019 German subsidiary Prolytic has accompanied Aeterna Zentaris in its development of pharmaceutical and diagnostic products. Katrin Dorfmeyer, Head of Chromatography, at Prolytic, and Dr. Michael Teifel, CSO at Aeterna Zentaris, shed light on the interesting project of the <strong>growth hormone secretagogue macimorelin (Macrilen, Ghryvelin)<\/strong> which they have been working on together for the last 10 years.<\/span><\/p>\n<p><span style=\"font-size: 14pt;\">Katrin Dorfmeyer begins with an explanation of why pharmaceutical and biotech companies in general turn to Prolytic: \u201cWe at Prolytic are known as specialist in chromatography namely <a href=\"https:\/\/kymos.com\/ca\/serveis\/serveis-preclinics-i-clinics\/bioanalisi-de-petites-molecules-i-generics\/\" data-wpel-link=\"internal\">bioanalysis of small molecules<\/a> with LC-MS\/MS. In the past our clients mostly contacted us with specific and difficult analytical projects because they knew that we would find a solution for them. In the case of Aeterna Zentaris, we started our first investigations in 2003 with the then state of the art RIA method but managed to develop an innovative LC-MS\/MS method, which no one had accomplished before.\u201d<\/span><\/p>\n<blockquote>\n<p><span style=\"font-size: 14pt;\">Dr. Teifel also recalls the close relationship Aeterna Zentaris and Prolytic have: &#8220;Over the years, Prolytic has supported us in many different projects with various analytes, including small molecules, peptidomimetics, peptides and peptide-drug conjugates. For the macimorelin project, we have been working with Prolytic for almost two decades now. Macimorelin (Macrilen, Ghryvelin) is the first and only U.S. FDA and EU approved oral test indicated for the diagnosis of adult growth hormone deficiency (AGHD). With our ongoing studies in children and adolescents we aim to make this test option also available in this population. Once again, Katrin Dorfmeyer&#8217;s team supports us with its excellent LC-MS\/MS analytical expertise.\u201d<\/span><\/p>\n<\/blockquote>\n<p><span style=\"font-size: 14pt;\">Katrin Dorfmeyer elaborates further: \u201cAs already mentioned, many clients have come to us in the past for complicated special cases. Since we merged with Kymos in 2020, more and more clients are also turning to us for large pre-clinical and clinical trials, which we now can handle routinely and quickly. Together with Kymos in Barcelona and Pharmaprogress in Ancona, we have three API-6500 two of them coupled to an Agilent UHPLC, two high-sensitivity APIs 5500 connected to a Waters UPLC Acquity, six API-4000 and one API-3200 (all triple SCIEX quadrupoles). We are now capable of processing more than 31,000 bioanalytical samples per month.\u201d<\/span><\/p>\n<blockquote>\n<p><span style=\"font-size: 14pt;\">Volume capabilities aside, Prolytic is still ready to tackle extremely complex topics. Katrin Dorfmeyer refers to our newest project: \u201cIn our BMBF-funded research project, we recently succeeded in developing an LC-MS\/MS method for the determination of <strong>prostaglandins in urine<\/strong>. Prostaglandins are extremely complicated to detect as endogenous markers due to their instability and difficult chromatographic separability. By means of a special solid phase extraction and a new standardisation procedure developed by our team, we were able to validate the LC-MS\/MS method according to GLP.\u201d<\/span><\/p>\n<\/blockquote>\n<p><span style=\"font-size: 14pt;\">\u201cThese scientific challenges motivate and inspire my team and me.\u201d she continues. \u201cYet, it is at least as satisfying that, as is the case for macimorelin (Macrilen, Ghryvelin), we are privileged to be part of a project that ultimately made it to the market, and contributing to improving human health.\u201d<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">Aeterna Zentaris is a specialty biopharmaceutical company developing and commercializing a diversified portfolio of pharmaceutical and diagnostic products focused on areas of significant unmet medical need. Find out more about Aeterna Zentaris and its projects at <a href=\"https:\/\/www.zentaris.com\/\" data-wpel-link=\"external\">https:\/\/www.zentaris.com\/<\/a> or contact them at <a href=\"mailto:aezs@jtcir.com\" data-wpel-link=\"internal\">aezs@jtcir.com<\/a><\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":15239,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[107,106],"tags":[62],"class_list":["post-22756","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kymos-group-ca","category-novetats","tag-joan"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bioan\u00e0lisi de prostaglandines a Prolytic\/Kymos<\/title>\n<meta name=\"description\" content=\"Prolytic t\u00e9 un m\u00e8tode validat per GLP per a la quantificaci\u00f3 de prostaglandines a l&#039;orina. 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Experience Joan Puig de Dou started his career at Laboratorios Menarini first as scientist later as Qualified Person and finally as Operations General Manager. 2010 he entered Kymos where he became CEO in 2015. 2022 Joan Puig de Dou was elected as president of CataloniaBio&amp;HealthTech to represent the Catalonian biotech industry nationally and internationally. Expertise Joan Puig de Dou has extensive experience in writing scientific content adopting a didactic approach that fits any reader\u2019s level of expertise. He publishes regularely on Kymos\u2019 webpage, social media and in the specialized press. Education He graduated from Universitat de Barcelona as Pharmacist and from IESE Business School\u2019s Programa Diecci\u00f3n General (PDG) Want to know him better? Read his interview in PharmaBoardrooom in January 2019 and more about his presidency of CataloniaBio at Parc Sc\u00edentific de Barcelona.","url":"https:\/\/kymos.com\/ca\/news\/author\/joan-puig-de-dou\/"}]}},"_links":{"self":[{"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/posts\/22756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/comments?post=22756"}],"version-history":[{"count":0,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/posts\/22756\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/media\/15239"}],"wp:attachment":[{"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/media?parent=22756"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/categories?post=22756"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kymos.com\/ca\/wp-json\/wp\/v2\/tags?post=22756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}