{"id":22703,"date":"2018-07-07T13:25:50","date_gmt":"2018-07-07T11:25:50","guid":{"rendered":"https:\/\/kymos.com\/news\/prova-dactivitat-antifactor-de-lheparina\/"},"modified":"2018-07-07T13:25:50","modified_gmt":"2018-07-07T11:25:50","slug":"prova-dactivitat-antifactor-de-lheparina","status":"publish","type":"post","link":"https:\/\/kymos.com\/ca\/news\/prova-dactivitat-antifactor-de-lheparina\/","title":{"rendered":"Prova d’activitat antifactor de l’heparina"},"content":{"rendered":"

L’heparina<\/strong> \u00e9s un glicosaminoglic\u00e0 sulfatat que es presenta com una barreja de mol\u00e8cules heterog\u00e8nies que varien en pes molecular i que s’utilitza en medicina com a anticoagulant. \u00c9s present en els teixits dels mam\u00edfers i normalment s’obt\u00e9 de la mucosa intestinal o altres teixits adequats de mam\u00edfers dom\u00e8stics per a l’alimentaci\u00f3 humana. Es purifica per conservar una combinaci\u00f3 d’activitats contra diferents fraccions de la seq\u00fc\u00e8ncia de coagulaci\u00f3 de la sang. Est\u00e0 composta de pol\u00edmers de derivats alterns de D-glucosamina (N-sulfata, O-sulfata o N-acetilada) i ur\u00f2nic (\u00e0cid L-idur\u00f2nic o \u00e0cid D-glucur\u00f2nic) units per enlla\u00e7os glios\u00eddics. El fraccionament de les heparines produeix les heparines de baix pes molecular (HBPM) que mostren alguns avantatges respecte a les heparines no fraccionades. <\/span><\/p>\n

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Hist\u00f2ria recent<\/span><\/h3>\n

En resposta a la crisi d’adulteraci\u00f3 d’heparina del 2007\/2008 que va causar almenys 81 morts als Estats Units a causa d’una adulteraci\u00f3 amb condroitina sulfat sobresulfatat<\/b> (OSCS) de la mat\u00e8ria primera fabricada a la Xina, les farmacopees dels EUA i la UE van revisar les seves monografies d’heparina .<\/b> USP32-NF27 i Ph Eur. Ed. 7a<\/sup> van incloure l’aplicaci\u00f3 de t\u00e8cniques anal\u00edtiques ortogonals com la 1<\/sup> H-RMN<\/strong> , la cromatografia d’intercanvi ani\u00f2nic<\/strong> i l’electroforesi capil\u00b7lar<\/strong> per confirmar l’abs\u00e8ncia de l’OSCS. A m\u00e9s, l’assaig de coagulaci\u00f3 anterior en plasma ov\u00ed va ser substitu\u00eft per assaigs m\u00e9s espec\u00edfics per a l’activitat anti-factor IIa<\/strong> i l’activitat anti-factor Xa<\/strong> . <\/span><\/p>\n

<\/h3>\n

Base cient\u00edfica de la prova<\/span><\/h3>\n

El factor Xa i el factor IIa o trombina s\u00f3n prote\u00efnes hidrol\u00edticas o peptidases que tenen un paper en la via final comuna de la cascada de coagulaci\u00f3. El factor Xa interv\u00e9 en la transformaci\u00f3 de la protrombina en factor II. El factor II, alhora, interv\u00e9 en la conversi\u00f3 del fibrinogen soluble en fibrina, que \u00e9s insoluble, i forma el teixit. <\/span><\/p>\n

Protrombina + Factor Xa \u2192 Factor IIa<\/b><\/span><\/p>\n

Fibrinogen + Factor IIa \u2192 Fibrina (tela) <\/b><\/span><\/p>\n

L’activitat del factor IIa i Xa \u00e9s inhibida per l’antitrombina (AT), que modula la cascada de coagulaci\u00f3: un augment de l’activitat de l’AT produir\u00e0 una disminuci\u00f3 de la coagulaci\u00f3 i viceversa. L’heparina s’uneix a l’AT produint un canvi conformacional que augmenta el seu efecte inhibidor sobre el factor IIa i Xa. Aquesta potenciaci\u00f3 del resultat inhibidor sobre aquestes peptidases provoca l’efecte anticoagulant de les heparines en l’\u00fas farmacol\u00f2gic. Les heparines de baix pes molecular catalitzen la reacci\u00f3 entre el factor IIa i l’antitrombina amb menys facilitat que la reacci\u00f3 que implica el factor Xa<\/b> . Per contra, l’heparina no fraccionada catalitza ambdues reaccions per igual. <\/span><\/p>\n

<\/h3>\n

Contribuci\u00f3 de Kymos<\/span><\/h3>\n

Els kits disponibles comercialment no sempre s\u00f3n una bona soluci\u00f3 i poden necessitar millores en funci\u00f3 de l’origen de l’heparina, la concentraci\u00f3, els contaminants i altres factors. La implementaci\u00f3 de la prova compendial de la Farmacopea tamb\u00e9 \u00e9s complexa, fins i tot en laboratoris amb experi\u00e8ncia en aquest tipus de prova, i es recomana una validaci\u00f3 del m\u00e8tode. Kymos t\u00e9 desenvolupats i validats els m\u00e8todes de la Ph.D. Europea i la USP i ofereix serveis de proves en compliment de les GMP. M\u00e9s informaci\u00f3 sobre els nostres serveis GMP per a biol\u00f2gics i biosimilars<\/a> . <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

L’heparina \u00e9s un glicosaminoglic\u00e0 sulfatat que es presenta com una […]<\/p>\n","protected":false},"author":7,"featured_media":15005,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[97],"tags":[],"class_list":["post-22703","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cmc-ca"],"acf":[],"yoast_head":"\nProva d'activitat antifactor de l'heparina - Kymos<\/title>\n<meta name=\"description\" content=\"Proves d'activitat antifactor de l'heparina amb un m\u00e8tode validat a Kymosa segons la Farmac\u00e8utica Europea i la USP en compliment de les GMP.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kymos.com\/ca\/news\/prova-dactivitat-antifactor-de-lheparina\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prova d'activitat antifactor de l'heparina - 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